Evidence for two alternatively spliced forms of phospholipase C-beta2 in haematopoietic cells.

@article{Mao2000EvidenceFT,
  title={Evidence for two alternatively spliced forms of phospholipase C-beta2 in haematopoietic cells.},
  author={Guang Fen Mao and Satya P Kunapuli and A Koneti Rao},
  journal={British journal of haematology},
  year={2000},
  volume={110 2},
  pages={402-8}
}
Alternatively spliced forms have been reported for several phospholipase C (PLC) isozymes, but not for PLC-beta2, the most abundant PLC-beta in platelets. PLC-beta2 cDNA cloned from the HL-60-cell cDNA library is 3543 bases long, coding for 1181 amino acids. Compared with the published sequence, a deletion of 45 nucleotides (2755-2799 nt, amino acids 864-878) was detected in platelet and leucocyte mRNA amplified by reverse transcription (RT) polymerase chain reaction (PCR) using primers… CONTINUE READING