Evidence for turnover of functional noncoding DNA in mammalian genome evolution.

@article{Smith2004EvidenceFT,
  title={Evidence for turnover of functional noncoding DNA in mammalian genome evolution.},
  author={Nick G. C. Smith and Mikael D. Brandstr{\"o}m and Hans Ellegren},
  journal={Genomics},
  year={2004},
  volume={84 5},
  pages={806-13}
}
The vast majority of the mammalian genome does not code for proteins, and a fundamental question in genomics is: What proportion of the noncoding mammalian genome is functional? Most attempts to address this issue use sequence comparisons between highly diverged mammals such as human and mouse to identify conservation due to negative selection. But such comparisons will underestimate the true proportion of functional noncoding DNA if there is turnover, if patterns of negative selection change… CONTINUE READING