Evidence for translational regulation of the activator of general amino acid control in yeast.

  • Alan G Hinnebusch
  • Published 1984 in
    Proceedings of the National Academy of Sciences…


The GCN4 gene encodes a positive regulator of unlinked amino acid biosynthetic genes in yeast. I present evidence that the GCN4 gene is itself regulated by amino acid availability and that the regulation occurs at the translational level. A GCN4-lacZ fusion was used as a measure of the expression of GCN4 gene product. Starvation for histidine leads to… (More)

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