Evidence for transcriptional and post-transcriptional control of the cellular thymidine kinase gene.

@article{Stewart1987EvidenceFT,
  title={Evidence for transcriptional and post-transcriptional control of the cellular thymidine kinase gene.},
  author={C. J. Stewart and M. Ito and S. Conrad},
  journal={Molecular and cellular biology},
  year={1987},
  volume={7 3},
  pages={
          1156-63
        }
}
We have studied the cell cycle-regulated expression of the thymidine kinase (TK) gene in mammalian tissue culture cells. TK mRNA and enzyme levels are low in resting, G0-phase cells, but increase dramatically (10- to 20-fold) during the S phase in both serum-stimulated and simian virus 40-infected cells. To determine whether an increase in the rate of TK gene transcription is responsible for this induction, nuclear run-on transcription assays were performed at various times after serum… Expand
76 Citations
Regulation of thymidine kinase protein stability in serum-stimulated cells.
  • M. Carozza, S. E. Conrad
  • Biology, Medicine
  • Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
  • 1994
  • 4
  • PDF
Posttranscriptional control of thymidine kinase messenger RNA accumulation in cells released from G0-G1 phase blocks.
  • 15
  • PDF
Role of the promoter in the regulation of the thymidine kinase gene.
  • 41
  • PDF
Serum-responsive expression from the murine thymidine kinase promoter is specifically disrupted in a transformed cell line.
  • 5
  • PDF
Splicing signals are required for S-phase regulation of the mouse thymidylate synthase gene.
  • 35
  • PDF
Transcription initiation and temporal expression of thymidine kinase mRNA in Chinese hamster cells.
  • J. Gudas
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • 1992
  • 4
CCAAT‐box contributions to human thymidine kinase mRNA expression
  • 6
Growth-responsive expression from the murine thymidine kinase promoter: genetic analysis of DNA sequences.
  • 26
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 19 REFERENCES
Induction of cellular thymidine kinase occurs at the mRNA level.
  • 65
  • PDF
Post-transcriptional regulation of the chicken thymidine kinase gene.
  • 66
Transcriptional regulation of mouse dihydrofolate reductase in the cell cycle.
  • 92
Cell cycle regulation of mouse H3 histone mRNA metabolism.
  • 101
  • PDF
Regulation of human histone gene expression during the HeLa cell cycle requires protein synthesis.
  • 50
  • PDF
...
1
2
...