Evidence for transcriptional and post-transcriptional control of the cellular thymidine kinase gene.

@article{Stewart1987EvidenceFT,
  title={Evidence for transcriptional and post-transcriptional control of the cellular thymidine kinase gene.},
  author={Colin John Reid Stewart and Mutsumi Bunkyo-ku Ito and Susan E. Conrad},
  journal={Molecular and cellular biology},
  year={1987},
  volume={7 3},
  pages={
          1156-63
        }
}
We have studied the cell cycle-regulated expression of the thymidine kinase (TK) gene in mammalian tissue culture cells. TK mRNA and enzyme levels are low in resting, G0-phase cells, but increase dramatically (10- to 20-fold) during the S phase in both serum-stimulated and simian virus 40-infected cells. To determine whether an increase in the rate of TK gene transcription is responsible for this induction, nuclear run-on transcription assays were performed at various times after serum… CONTINUE READING

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