Evidence for tissue iron overload in long-term hemodialysis patients and the impact of withdrawing parenteral iron.

@article{Ghoti2012EvidenceFT,
  title={Evidence for tissue iron overload in long-term hemodialysis patients and the impact of withdrawing parenteral iron.},
  author={Hussam Ghoti and Eliezer A. Rachmilewitz and Ramon Simon-Lopez and Raed Gaber and Zeev Katzir and Eli Konen and Tamar Kushnir and Domenico Girelli and Natascia Campostrini and Eitan Fibach and Orly Goitein},
  journal={European journal of haematology},
  year={2012},
  volume={89 1},
  pages={
          87-93
        }
}
BACKGROUND/AIMS Erythropoiesis in long-term hemodialyzed (LTH) patients is supported by erythropoietin (rHuEpo) and intravenous (IV) iron. This treatment may end up in iron overload (IO) in major organs. We studied such patients for the parameters of IO in the serum and in major organs. METHODS Patients were treated with rHuEpo (6-8 x 10(3) units × 1-3/wk) and IV 100 mg ferric saccharate. RESULTS Of 115 patients, 21 had serum ferritin (SF) > 1000 ng/mL. This group was further analyzed… CONTINUE READING
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