Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain

  title={Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain},
  author={Michael Angus Crawford and M. B. D. Bloom and C. Leigh Broadhurst and Walter F. Schmidt and Stephen C. Cunnane and Claudio Galli and K. Gehbremeskel and Frank M. Linseisen and James O. Lloyd-Smith and John Parkington},
The African savanna ecosystem of the large mammals and primates was associated with a dramatic decline in relative brain capacity associated with little docosahexaenoic acid (DHA), which is required for brain structures and growth. The biochemistry implies that the expansion of the human brain required a plentiful source of preformed DHA. The richest source of DHA is the marine food chain, while the savanna environment offers very little of it. ConsequentlyHomo sapiens could not have evolved on… 
Docosahexaenoic acid, the aquatic diet, and hominin encephalization: Difficulties in establishing evolutionary links
  • B. Carlson, J. Kingston
  • Biology
    American journal of human biology : the official journal of the Human Biology Council
  • 2007
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Nutritional armor in evolution: docosahexaenoic acid as a determinant of neural, evolution and hominid brain development.
It is suggested that the present paradigm of food production currently based on protein requirements, should change to serve the specific lipid needs of the brain to address the rise in mental ill-health.
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Adaptive Evolution of the FADS Gene Cluster within Africa
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A multidisciplinary reconstruction of Palaeolithic nutrition that holds promise for the prevention and treatment of diseases of civilisation
The evidence for the long-reigning hypothesis of human evolution on the arid savanna is weighed against the hypothesis that man evolved in the proximity of water and the composition and merits of so-called 'Palaeolithic diets' are evaluated.
ARTÍCULOS DE ACTUALIZACIÓN Ácido docosahexaenoico (DHA), un ácido graso esencial a nivel cerebral Docosahexaenoic acid (DHA), an essential fatty acid at the brain
The importance of DHA in the human brain is reviewed and the importance of this fatty acid in the development of the tissue and as neuroprotective agent is discussed, which includes a critical view about the use of this noble fatty acids in the population.


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P Paleoanthropological evidence clearly indicates that hominids evolved in East Africa, and that early Homo inhabited the Rift Valley lake shores, and 'brain-specific' nutrition had and still has significant potential to affect hominid brain evolution.
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  • Biology
    The Proceedings of the Nutrition Society
  • 1975
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  • Biology
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 1997
The results suggest that the intake of DHA itself increases the DHA level of brain membranes more rapidly than intake of the precursors in animals fed a low n-3 fatty acid level diet.
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Abstract The Middle Stone Age (MSA) asociated hominids from Klasies River Mouth (KRM) have taken on a key role in debate about the origins of modern humans, with their craniofacial remains seen as
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