Evidence for the spatial separation of the binding sites for substrate and for cytoskeletal proteins on the enzyme aldolase.

@article{Humphreys1986EvidenceFT,
  title={Evidence for the spatial separation of the binding sites for substrate and for cytoskeletal proteins on the enzyme aldolase.},
  author={L. R. Humphreys and Steven Reid and Colin J. Masters},
  journal={The International journal of biochemistry},
  year={1986},
  volume={18 1},
  pages={
          7-13
        }
}
  • L. R. Humphreys, Steven Reid, Colin J. Masters
  • Published in
    The International journal of…
    1986
  • Biology, Medicine
  • The effect of the proteolysis of aldolase on both the substrate specificity of the enzyme and binding capacity for actin have been studied. Carboxypeptidase A, trypsin, chymotrypsin and pepsin, all acted to cleave peptides from the C-terminal portion of the enzyme, resulting initially in a marked loss of activity towards fructose-1:6-bisphosphate (FBP), without impairment of activity towards fructose-1-phosphate (F1P). In some cases, however, further proteolysis caused reductions in activity… CONTINUE READING

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