Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.

@article{Flashman2010EvidenceFT,
  title={Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.},
  author={Emily Flashman and Lee Michael Hoffart and Refaat B Hamed and J Martin Bollinger and Carsten Krebs and Christopher J. Schofield},
  journal={The FEBS journal},
  year={2010},
  volume={277 19},
  pages={
          4089-99
        }
}
The response of animals to hypoxia is mediated by the hypoxia-inducible transcription factor. Human hypoxia-inducible factor is regulated by four Fe(II)- and 2-oxoglutarate-dependent oxygenases: prolyl hydroxylase domain enzymes 1-3 catalyse hydroxylation of two prolyl-residues in hypoxia-inducible factor, triggering its degradation by the proteasome. Factor inhibiting hypoxia-inducible factor catalyses the hydroxylation of an asparagine-residue in hypoxia-inducible factor, inhibiting its… CONTINUE READING
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