Evidence for the role of oxidative stress in the acetylation of histone H3 by ethanol in rat hepatocytes.

@article{Choudhury2010EvidenceFT,
  title={Evidence for the role of oxidative stress in the acetylation of histone H3 by ethanol in rat hepatocytes.},
  author={Mahua Choudhury and Pil-hoon Park and Daniel Jackson and Shivendra D. Shukla},
  journal={Alcohol},
  year={2010},
  volume={44 6},
  pages={531-40}
}
The relationship between ethanol-induced oxidative stress and acetylation of histone H3 at lysine 9 (H3AcK9) remains unknown and was therefore investigated in primary cultures of rat hepatocytes. Cells were treated with ethanol, and a select group of pharmacological agents and the status of H3AcK9 and reactive oxygen species (ROS) were monitored. Pretreatment of hepatocytes with N-acetyl cystein (ROS reducer), or dietary antioxidants (quercetin, reserveratrol), or NADPH (reduced nicotinamide… CONTINUE READING
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