Evidence for the role of nitric oxide in macula densa control of glomerular hemodynamics.

@article{Ito1993EvidenceFT,
  title={Evidence for the role of nitric oxide in macula densa control of glomerular hemodynamics.},
  author={Sadayoshi Ito and Yan-hua Ren},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 2},
  pages={1093-8}
}
There is evidence that nitric oxide, an endothelium-derived relaxing factor, may be produced by the macula densa, as well as by blood vessels, within the kidney. To examine the role of nitric oxide in macula densa control of glomerular hemodynamics directly, we performed in vitro microperfusions of both rabbit afferent arterioles (with the glomerulus intact) and adherent tubular segments consisting of portions of the thick ascending limb, macula densa, and early distal tubule. While keeping… CONTINUE READING