Evidence for the role of megalin in renal uptake of transthyretin.

  title={Evidence for the role of megalin in renal uptake of transthyretin.},
  author={Monica Sousa and Anthony G. W. Norden and Christian Jacobsen and Thomas E. Willnow and Erik Ils\o Christensen and Rajesh V Thakker and Pierre J. Verroust and S\oren K Moestrup and Maria Jo{\~a}o Saraiva},
  journal={The Journal of biological chemistry},
  volume={275 49},
The kidney is a major organ for uptake of the thyroid hormone thyroxine (T(4)) and its conversion to the active form, triiodothyronine. In the plasma, one of the T(4) carriers is transthyretin (TTR). In the present study we observed that TTR, the transporter of both T(4) and retinol-binding protein, binds to megalin, the multiligand receptor expressed on the luminal surface of various epithelia including the renal proximal tubules. In the kidney, megalin plays an important role in tubular… CONTINUE READING


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