Evidence for the progressive nature of neoplastic transformation in vitro.

  title={Evidence for the progressive nature of neoplastic transformation in vitro.},
  author={Jeffrey C. Barrett and Paul O. P. Ts'o},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={75 8},
The temporal acquisition of in vitro phenotypes associated with neoplasia were examined after exposure of Syrian hamster embryo cells to a chemical carcinogen. Quantitative assays measuring morphological changes, enhanced fibrinolytic activity, and anchorage independent growth were used to detect the development of transformed cells within a population of normal hamster embryo cells. Morphological transformation and enhanced fibrinolytic activity were early changes observed after treatment with… CONTINUE READING
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