Evidence for the presence of stem cell-like progenitor cells in human adult pancreas.

@article{Zhao2007EvidenceFT,
  title={Evidence for the presence of stem cell-like progenitor cells in human adult pancreas.},
  author={Min Zhao and Stephanie A. Amiel and Michael R. Christie and Paolo Muiesan and Parthi Srinivasan and Wendy Littlejohn and Mohamed Rela and Matthew Arno and Nigel Heaton and Guo Cai Huang},
  journal={The Journal of endocrinology},
  year={2007},
  volume={195 3},
  pages={407-14}
}
The origin of cells replacing ageing beta-cells in adult life is unknown. This study assessed the expression of classic stem cell markers: Oct4, Sox2 and CD34 in islet-enriched fractions versus exocrine cell-enriched fractions from 25 adult human pancreases following human islet isolation. Expression of Oct4, Sox2 and CD34 mRNAs was found in all cell samples, with no significant differences between endocrine and exocrine cell fractions. Immunohistochemical staining for Oct4, Sox2, CD133, CD34… CONTINUE READING

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