Evidence for the presence of angiogenin in human follicular fluid and the up-regulation of its production by human chorionic gonadotropin and hypoxia.

@article{Koga2000EvidenceFT,
  title={Evidence for the presence of angiogenin in human follicular fluid and the up-regulation of its production by human chorionic gonadotropin and hypoxia.},
  author={Kaori Koga and Yutaka Osuga and Osamu Tsutsumi and Mikio Momoeda and Aya Suenaga and Koji Kugu and Toshiyuki Fujiwara and Yasushi Takai and Tetsu Yano and Yuji Taketani},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2000},
  volume={85 9},
  pages={3352-5}
}
Angiogenesis is an essential event during the development of the ovarian follicle and ensuing formation of the corpus luteum. We investigated the presence of angiogenin, a potent inducer of angiogenesis, and the regulatory mechanisms of its production in the human ovary. Follicular fluid (FF) and granulosa cells (GCs) were collected from women undergoing in vitro fertilization and embryo transfer. The presence of angiogenin in FF and GCs was demonstrated by Western blot analysis. The production… CONTINUE READING

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