Evidence for the presence of GPRC6A receptors in rat mesenteric arteries.

@article{Harno2008EvidenceFT,
  title={Evidence for the presence of GPRC6A receptors in rat mesenteric arteries.},
  author={Erika Harno and Gillian Edwards and Annie R Geraghty and Donald T. Ward and Robert H Dodd and Philippe Dauban and H{\'e}l{\`e}ne Faure and Martial Ruat and Arthur H. Weston},
  journal={Cell calcium},
  year={2008},
  volume={44 2},
  pages={210-9}
}
In this study, the presence of GPRC6A receptors in rat mesenteric artery was investigated. In artery homogenates, GPRC6A mRNA was detected and Western blotting showed the presence of GPRC6A protein. Immunohistochemical studies revealed GPRC6A in both endothelial cells and myocytes. In whole vessel segments, the GPRC6A activators, 300 microM l-ornithine and 100 microM Al(3+), induced endothelium-dependent myocyte hyperpolarizations sensitive to 10 microM TRAM-34, a blocker of intermediate… CONTINUE READING

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