Evidence for the presence of GPRC6A receptors in rat mesenteric arteries.

  title={Evidence for the presence of GPRC6A receptors in rat mesenteric arteries.},
  author={Erika Harno and Gillian Edwards and Annie R Geraghty and Donald T. Ward and Robert H Dodd and Philippe Dauban and H{\'e}l{\`e}ne Faure and Martial Ruat and Arthur H. Weston},
  journal={Cell calcium},
  volume={44 2},
In this study, the presence of GPRC6A receptors in rat mesenteric artery was investigated. In artery homogenates, GPRC6A mRNA was detected and Western blotting showed the presence of GPRC6A protein. Immunohistochemical studies revealed GPRC6A in both endothelial cells and myocytes. In whole vessel segments, the GPRC6A activators, 300 microM l-ornithine and 100 microM Al(3+), induced endothelium-dependent myocyte hyperpolarizations sensitive to 10 microM TRAM-34, a blocker of intermediate… CONTINUE READING


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Publications referenced by this paper.
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Identification of a novel extracellular cation-sensing G-protein-coupled receptor.

The Journal of biological chemistry • 2005
View 7 Excerpts
Highly Influenced

Molecular cloning

P. Wellendorph, H. Brauner-Osborne
expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor, Gene 335 • 2004
View 4 Excerpts
Highly Influenced

Aromatic Lamino acids activate the calciumsensing receptor

H. C. Mun A. D. Conigrave, H. C. Lok
J . Nutr . • 2007

Pharmacological characterization of mouse GPRC 6 A , an Lalphaamino - acid receptor modulated by divalent cations

K. B. Hansen, P. Wellendorph, H. Brauner-Osborne
Br . J . Pharmacol . • 2007

The rat GPRC 6 A : cloning and characterization

H. Brauner-Osborne

Broad - spectrum Lamino Endocrinol

D. R. Hampson

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