Evidence for the pivotal role of endogenous toll-like receptor 4 ligands in liver ischemia and reperfusion injury.

@article{Zhai2008EvidenceFT,
  title={Evidence for the pivotal role of endogenous toll-like receptor 4 ligands in liver ischemia and reperfusion injury.},
  author={Yuan Zhai and Bo Qiao and Xiu-da Shen and Feng Gao and Ronald W Busuttil and Genhong Cheng and Jeffrey L Platt and H P Volk and Jerzy W. Kupiec-Weglinski},
  journal={Transplantation},
  year={2008},
  volume={85 7},
  pages={1016-22}
}
BACKGROUND Although toll-like receptor 4 (TLR4) activation has been demonstrated to play a key role in the induction of intrahepatic inflammation, leading to hepatocellular damage in liver ischemia/reperfusion injury (IRI), the nature of TLR4 ligands generated during tissue injury remains to be elucidated. We hypothesized that endogenous TLR4 ligands, rather than endotoxin (lipopolysaccharide [LPS]), are instrumental in the activation of liver TLR4 leading to local inflammation response that… CONTINUE READING
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