Evidence for the modulation of sexual behavior by alpha-adrenoceptors in male rats.

@article{Clark1985EvidenceFT,
  title={Evidence for the modulation of sexual behavior by alpha-adrenoceptors in male rats.},
  author={Joshua T. Clark and Edward R Smith and Julian M. Davidson},
  journal={Neuroendocrinology},
  year={1985},
  volume={41 1},
  pages={36-43}
}
Clonidine, a commonly used antihypertensive agent believed to act by stimulation of central alpha-adrenoceptors, produced a dose-related suppression of ejaculatory behavior in sexually vigorous male rats throughout the range of treatment (0.0125-0.5 mg/kg). Treatment with 0.25 mg/kg virtually eliminated ejaculatory behavior, without altering the number of animals mounting and intromitting. These effects were maintained for at least 4 h after treatment. Prazosin, another antihypertensive (but… CONTINUE READING

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