Evidence for the involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear.

@article{Oka2005EvidenceFT,
  title={Evidence for the involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear.},
  author={Saori Oka and Shin Yanagimoto and Shinobu Ikeda and Maiko Gokoh and Seishi Kishimoto and Keizo Waku and Yoshio Ishima and Takayuki Sugiura},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 18},
  pages={18488-97}
}
2-Arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors. Two types of cannabinoid receptors have been identified to date. The CB1 receptor is abundantly expressed in the brain, and assumed to be involved in the attenuation of neurotransmission. On the other hand, the physiological roles of the CB2 receptor, mainly expressed in several types of inflammatory cells and immunocompetent cells, have not yet been fully elucidated. In this study, we investigated possible… CONTINUE READING

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