Evidence for the involvement of multiple mechanisms in the excitatory action of bradykinin in the circular muscle of guinea-pig colon

Abstract

We have investigated, by using the sucrose gap technique, the mechanisms of the excitatory action of bradykinin in the circular muscle of the guinea-pig proximal colon. In the presence of atropine (1μM) and S-ketoprofen (3μM), the application of bradykinin (1μM for 20s) produced complex changes in membrane potential and muscle tension. The prevailing… (More)
DOI: 10.1007/PL00005158

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