Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2

@article{Strassmann1994EvidenceFT,
  title={Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2},
  author={Gideon Strassmann and Vina Patil-Koota and Fred D. Finkelman and Miranda Fong and Taku Kambayashi},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={180},
  pages={2365 - 2370}
}
Among other effects, prostaglandins (PG) of the E series are known to inhibit several acute and chronic inflammatory conditions in vivo and proinflammatory cytokine production by activated macrophages in culture. The research presented here demonstrates that the inhibitory effect of PGE2 on tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) production by lipopolysaccharide (LPS)-stimulated murine peritoneal macrophages involves IL-10. In a dose-dependent manner, PGE2 inhibits LPS… CONTINUE READING
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