Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high‐functioning level

@article{Wermter2010EvidenceFT,
  title={Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high‐functioning level},
  author={A. Wermter and I. Kamp-Becker and Philipp Hesse and G. Schulte-K{\"o}rne and K. Strauch and H. Remschmidt},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2010},
  volume={153B}
}
  • A. Wermter, I. Kamp-Becker, +3 authors H. Remschmidt
  • Published 2010
  • Biology, Medicine
  • American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
  • An increasing number of animal studies advert to a substantial role of the neuropeptide oxytocin in the regulation of social attachment and affiliation. Furthermore, animal studies showed anxiety and stress‐reduced effects of oxytocin. First human studies confirm these findings in animal studies and implicate a crucial role of oxytocin in human social attachment behavior and in social interactions. Thus, the oxytocin system might be involved in the impairment of social interaction and… CONTINUE READING
    144 Citations

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    Oxytocin is a neuropeptide that is well known for its role in social and affiliative behavior in humans. Oxytocin receptors are significantly lowered in autistic individuals and… Expand
    ConditionsBrain Dynamics in Healthy Adults
    InterventionDrug
    Genetic variation in the oxytocin receptor gene is associated with a social phenotype in autism spectrum disorders
    • 16
    • PDF
    Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD
    • 72
    Genetic and epigenetic regulatory mechanisms of the oxytocin receptor gene (OXTR) and the (clinical) implications for social behavior
    • 13
    A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function
    • 466
    • PDF
    Meta‐analysis and association of two common polymorphisms of the human oxytocin receptor gene in autism spectrum disorder
    • 28
    • Highly Influenced
    Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder
    • 141
    Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case–control study
    • 71
    • Highly Influenced

    References

    SHOWING 1-10 OF 50 REFERENCES
    Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population
    • 490
    • Highly Influential
    Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism
    • 380
    • Highly Influential
    Oxytocin and experimental therapeutics in autism spectrum disorders.
    • 141
    • PDF
    Serotonin transporter gene-linked polymorphic region: allele distributions in relationship to body weight and in anorexia nervosa.
    • 116
    Oxytocin Increases Retention of Social Cognition in Autism
    • 642
    • PDF
    Oxytocin, vasopressin and pair bonding: implications for autism
    • 235
    Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans.
    • 371
    The neuroscience of affiliation: Forging links between basic and clinical research on neuropeptides and social behavior
    • 306
    • PDF