Evidence for the involvement of galectin-3 in mesenchymal stem cell suppression of allogeneic T-cell proliferation.

@article{Sioud2010EvidenceFT,
  title={Evidence for the involvement of galectin-3 in mesenchymal stem cell suppression of allogeneic T-cell proliferation.},
  author={Mouldy Sioud and Anne Mobergslien and Abdellatif Boudabous and Yngvar Fl\oisand},
  journal={Scandinavian journal of immunology},
  year={2010},
  volume={71 4},
  pages={267-74}
}
Human bone marrow-derived mesenchymal stem cells (MSC) are multipotent non-hematopoietic progenitors that have regulatory activity on immune cells. NOD- and Toll-like receptors (NLR, TLR) have several roles in immunity, including those relevant to pathogen recognition and shaping the course of immune responses by controlling gene expression. We have shown that these innate immune receptors are expressed by hematopoietic CD34+ progenitors and MSC. To uncover genes critical in MSC function, first… CONTINUE READING
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and can be inhibit their T - cell modulatory activity by impairing Notch signaling

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drive their migration and immunomodulating responses

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