Evidence for the involvement of folic acid in histidine synthesis in microorganisms.

@article{Broquist1957EvidenceFT,
  title={Evidence for the involvement of folic acid in histidine synthesis in microorganisms.},
  author={H. P. Broquist},
  journal={Archives of biochemistry and biophysics},
  year={1957},
  volume={70 1},
  pages={
          210-6
        }
}
  • H. P. Broquist
  • Published 1957
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • When Torula cremoris was cultured in a simple medium in which the nitrogen source was principally ammonium sulfate, the organism was readily inhibited by aminopterin, a folic acid antagonist. The growth inhibition by aminopterin was overcome in a noncompetitive fashion by the stepwise addition of methionine, adenine, and histidine. Histidine was ineffective in counteracting aminopterin toxicity in the absence of adenine. When Lactobacillus arabinosus was cultured in a synthetic medium… CONTINUE READING
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