Evidence for the involvement of dopamine receptors in ethanol-induced hyperactivity in mice

@article{Cohen1997EvidenceFT,
  title={Evidence for the involvement of dopamine receptors in ethanol-induced hyperactivity in mice},
  author={C. Cohen and G. Perrault and D. Sanger},
  journal={Neuropharmacology},
  year={1997},
  volume={36},
  pages={1099-1108}
}
Based on the hypothesis that drugs of abuse increase locomotor activity through mechanisms related to reinforcement, i.e. the mesolimbic dopamine (DA) system, ethanol-induced hyperactivity might provide a screening model to investigate the effect of ethanol on reward pathways. In the present study, ethanol had bidirectional effects on locomotion in mice: hyperactivity at low doses (2-3 g/kg) and sedation at high doses (4-5 g/kg). Such high doses induced a loss of righting reflex (LRR). The… Expand
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Investigation of the relative involvement of D3 versus D2 dopamine receptors in the effects of dopamine ligands on the reinforcing action of ethanol found that reduction of dopamine transmission was associated with a decrease in ethanol-reinforced responding. Expand
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CB1 Receptor Knockout Mice Display Reduced Ethanol-Induced Conditioned Place Preference and Increased Striatal Dopamine D2 Receptors
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