Evidence for the involvement of dopamine receptors in ethanol-induced hyperactivity in mice

@article{Cohen1997EvidenceFT,
  title={Evidence for the involvement of dopamine receptors in ethanol-induced hyperactivity in mice},
  author={C. Cohen and G. Perrault and D. Sanger},
  journal={Neuropharmacology},
  year={1997},
  volume={36},
  pages={1099-1108}
}
Based on the hypothesis that drugs of abuse increase locomotor activity through mechanisms related to reinforcement, i.e. the mesolimbic dopamine (DA) system, ethanol-induced hyperactivity might provide a screening model to investigate the effect of ethanol on reward pathways. In the present study, ethanol had bidirectional effects on locomotion in mice: hyperactivity at low doses (2-3 g/kg) and sedation at high doses (4-5 g/kg). Such high doses induced a loss of righting reflex (LRR). The… Expand
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