Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene.

@article{Yavuz2002EvidenceFT,
  title={Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene.},
  author={Akif Selim Yavuz and Peter E Lipsky and Sule Yavuz and Dean D Metcalfe and Cem Akin},
  journal={Blood},
  year={2002},
  volume={100 2},
  pages={661-5}
}
Mast cells are derived from multipotential hematopoietic progenitors and are clonally increased in systemic mastocytosis, a disease associated with point mutations of codon 816 (most commonly Asp816Val) of c-kit. To study the lineage relationship and the extent of expansion of cells derived from the mutated clone, we examined the occurrence of the Asp816Val c-kit mutation in genomic DNA of individual sorted peripheral blood T cells, B cells, and monocytes in patients with indolent systemic… CONTINUE READING

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