Evidence for the involvement of B lymphoid cells in polycythemia vera and essential thrombocythemia.

@article{Raskind1985EvidenceFT,
  title={Evidence for the involvement of B lymphoid cells in polycythemia vera and essential thrombocythemia.},
  author={Wendy H Raskind and Robert J. Jacobson and Scott A Murphy and John W See Adamson and Philip J. Fialkow},
  journal={The Journal of clinical investigation},
  year={1985},
  volume={75 4},
  pages={1388-90}
}
Previous studies with the X-chromosome-linked glucose-6-phosphate dehydrogenase (G6PD) as a marker of cellular mosaicism demonstrated that polycythemia vera (PV) and essential thrombocythemia (ET) are clonal disorders of hematopoietic stem cells that can differentiate to erythrocytes, granulocytes, and platelets. To determine if the involved stem cells could also differentiate along the B-lymphoid pathway, we studied one woman with PV and one woman with ET. Of 117 Epstein-Barr virus-transformed… CONTINUE READING
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