Evidence for the importance of 5'-deoxy-5-fluorouridine catabolism in humans from 19F nuclear magnetic resonance spectrometry.

@article{MaletMartino1986EvidenceFT,
  title={Evidence for the importance of 5'-deoxy-5-fluorouridine catabolism in humans from 19F nuclear magnetic resonance spectrometry.},
  author={Marie-C. Malet-Martino and Jean Pierre Armand and Andr{\'e} Lopez and Jean Bernadou and J P B{\'e}teille and M. Bon and Robert Martino},
  journal={Cancer research},
  year={1986},
  volume={46 4 Pt 2},
  pages={2105-12}
}
The use of a new methodology, 19F nuclear magnetic resonance, has allowed detection of all the fluorinated metabolites in the biofluids of patients treated with 5'-deoxy-5-fluorouridine (5'-dFUrd) injected i.v. at a dose of 10 g/m2 over 6 h. This technique, which requires no labeled drug, allows a direct study of the biological sample with no need for extraction or derivatization and a simultaneous identification and quantitation of all the different fluorinated metabolites. As well as the… CONTINUE READING

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