Evidence for the histamine-mediated myotropic effect of angiotensin II in the rabbit aorta.


Histamine H1-receptor antagonist mepyramine and H2-receptor antagonist metiamide, respectively diminished and potentiated angiotensin II(A II)-induced myotropic responses in the rabbit aortic strips. The responses of the octapeptide were also inhibited in the presence of histidine decarboxylase inhibitor, 2-hydroxy-5-carbomethoxybenzoxyamine and restored… (More)


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