Evidence for the genetic control of estradiol-regulated responses. Implications for variation in normal and pathological hormone-dependent phenotypes.

@article{Griffith1997EvidenceFT,
  title={Evidence for the genetic control of estradiol-regulated responses. Implications for variation in normal and pathological hormone-dependent phenotypes.},
  author={Jon Griffith and Shawn M Jensen and Jared K Lunceford and Michael W Kahn and Ye Zheng and E A Falase and C. Richard Lyttle and Cory Teuscher},
  journal={The American journal of pathology},
  year={1997},
  volume={150 6},
  pages={2223-30}
}
The ovarian steroid hormone estrogen (E2) elicits a multiplicity of both systemic and uterotropic responses in vivo. For example, the administration of E2 to ovariectomized (Ovx) and sexually immature rodents leads to uterine-specific inflammatory infiltrates. In this study, we quantitated the number of eosinophils and BM8+, Ia+, and CD4+ cells in uteri obtained from adult Ovx control and E2-treated C57BL/6J, C3H/HeJ, and (C57BL/6J x C3H/HeJ) (B6C3) F1 hybrid mice. All three strains exhibited a… CONTINUE READING
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