Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae.

@article{Rajakumar2004EvidenceFT,
  title={Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae.},
  author={Augustine Rajakumar and Helene Brandon and Ashi R Daftary and Roberta Ness and Kirk P. Conrad},
  journal={Placenta},
  year={2004},
  volume={25 10},
  pages={763-9}
}
Placentas from women with preeclampsia overexpress the hypoxia-inducible transcription factor proteins, HIF-1alpha and -2alpha (Rajakumar 2001, Biol Reprod 64; p499-506 and p1019-1020). As a first step in evaluating whether HIF-alpha overexpressed in preeclamptic placentae is capable of transactivation, we tested its ability to bind to the DNA hypoxia… CONTINUE READING