Evidence for the founder effect of RET533 as the common Greek and Brazilian ancestor spreading multiple endocrine neoplasia 2A.

@article{Cunha2017EvidenceFT,
  title={Evidence for the founder effect of RET533 as the common Greek and Brazilian ancestor spreading multiple endocrine neoplasia 2A.},
  author={Lucas Cunha and Susan Lindsey and Maria Inez C França and Leda Sarika and Alexandra Papathoma and Ilda Shizue Kunii and Janete M Cerutti and Magnus R{\'e}gios Dias-da-Silva and Maria K Alevizaki and Rui Monteiro de Barros Maciel},
  journal={European journal of endocrinology},
  year={2017},
  volume={176 5},
  pages={515-519}
}
OBJECTIVES About one-quarter of patients with medullary thyroid cancer (MTC) have inherited disease due to mutations in the RET gene. A rare mutation in exon 8 (G533C) of RET, previously described in a large Brazilian family with MEN2A, also appeared to be clustering in Greece, whereas it was rarely reported in other ethnic groups. The aim of this study was to identify a possible common ancestry between these carriers. PATIENTS AND METHODS Twelve RET G533C mutation carriers, four randomly… CONTINUE READING

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About one - quarter of patients with medullary thyroid cancer ( MTC ) have inherited disease due to mutations in the RET gene .
About one - quarter of patients with medullary thyroid cancer ( MTC ) have inherited disease due to mutations in the RET gene .
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