Evidence for the formation of a known toxin, p-cresol, from menthofuran.

  title={Evidence for the formation of a known toxin, p-cresol, from menthofuran.},
  author={K. M. Madyastha and C. P. Raj},
  journal={Biochemical and biophysical research communications},
  volume={177 1},
  • K. M. Madyastha, C. P. Raj
  • Published 1991
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • Menthofuran (II, 4,5,6,7-tetrahydro-3,6-dimethyl benzofuran), the proximate toxin of R-(+)-pulegone (I), was administered orally to rats (200 mg/kg of body weight/day) for three days and the urinary metabolites were investigated. Among the several metabolites formed, two of them viz. 4-Hydroxy-4-methyl-2-cyclohexenone (VII) and p-cresol (VIII) were identified. In support of the formation of these metabolites, it has been demonstrated that phenobarbital induced rat liver microsomes readily… CONTINUE READING
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