Evidence for the existence of an HP1-mediated subcode within the histone code

  title={Evidence for the existence of an HP1-mediated subcode within the histone code},
  author={Gwen A. Lomberk and Debora Bensi and Martin E Fernandez-Zapico and Raul A Urrutia},
  journal={Nature Cell Biology},
Currently, the mammalian heterochromatic proteins HP1α, HP1β and the pan-nuclear HP1γ are considered 'gatekeepers' of methyl-K9-H3-mediated silencing. Understanding how the binding of these proteins to post-translationally modified histones is switched on and off will further our knowledge of how the histone code is modulated. Here, we report that all three HP1 isoforms can be extensively modified, similar to histones, suggesting that the silencing of gene expression may be further regulated… CONTINUE READING
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Structural basis of HP1–PXVXL motif peptide interactions and HP1 localisation to heterochromatin

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