Evidence for the existence of a proteasome in Toxoplasma gondii: intracellular localization and specific peptidase activities.

@article{Paugam2001EvidenceFT,
  title={Evidence for the existence of a proteasome in Toxoplasma gondii: intracellular localization and specific peptidase activities.},
  author={A. Paugam and Claudine Creuzet and Jean Dupouy-Camet and Marie Paule Roisin},
  journal={Parasite},
  year={2001},
  volume={8 4},
  pages={267-73}
}
The proteasome is a large intracellular protein complex whose main function is proteolytic removal of damaged proteins. It has recently been shown that the proteasome has a crucial role in the pathogenesis of protozoan parasites. We attempted to characterize the proteasome of T. gondii (RH strain). In immunoblot experiments, we showed that MCP231 monoclonal antibody, directed against the human 20S proteasome, labelled homologous proteins in T. gondii with a pattern similar to that observed in… CONTINUE READING