Evidence for the existence of a novel pregnancy-associated soluble variant of the vascular endothelial growth factor receptor, Flt-1.

@article{Banks1998EvidenceFT,
  title={Evidence for the existence of a novel pregnancy-associated soluble variant of the vascular endothelial growth factor receptor, Flt-1.},
  author={Rosamonde Elizabeth Banks and M. Allen Forbes and John S. Searles and Darryl Pappin and Benito Ca{\~n}as and Dr.Mujeebur Rahman and Scott Kaufmann and Claire E. Walters and Angela Leckie Jackson and P. Taylor Eves and Gretchen Linton and James P. Keen and James J. Walker and Peter John Selby},
  journal={Molecular human reproduction},
  year={1998},
  volume={4 4},
  pages={
          377-86
        }
}
Angiogenesis is essential in physiological processes including ovulation, implantation and pregnancy. One of the most potent regulators is the cytokine vascular endothelial growth factor (VEGF). We provide evidence for a novel pregnancy-associated soluble variant of the VEGF receptor Flt-1. VEGF ranged from undetectable to 157.3 pg/ml (mean 49.9 pg/ml, SD 48.4 pg/ml) in plasma samples from normal volunteers (n = 10), but was undetectable in plasma from pregnant women (n = 12) and amniotic fluid… CONTINUE READING
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Concentration of free vascular endothelial growth factor and its soluble receptor, sFlt-1 in the maternal and fetal circulations of normal term pregnancies at high and low altitudes.

  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
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