Evidence for the existence of a constitutive nitric oxide synthase in vascular smooth muscle.

@article{Cheah2002EvidenceFT,
  title={Evidence for the existence of a constitutive nitric oxide synthase in vascular smooth muscle.},
  author={L S Cheah and Mce Gwee and Rapti Das and H Glenn Ballard and Yubo Yang and Edwin E. Daniel and Chiu-yin Kwan},
  journal={Clinical and experimental pharmacology & physiology},
  year={2002},
  volume={29 8},
  pages={725-7}
}
1. We have identified a neuronal nitric oxide synthase (NOS)-like constitutive form of NOS in vascular smooth muscle (VSM) using a functional contractility approach as well as immunohistochemical methods. 2. N(G)-Nitro-L-arginine methyl ester, N(G)-monomethyl-L- arginine and N(G)-nitro-L-arginine (L-NOARG), the competitive inhibitors of NOS, inhibited Mg(2+)-induced relaxation of de-endothelialized rat aorta precontracted with phenylephrine (PE). This Mg(2+) relaxation of VSM was not affected… CONTINUE READING

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