Evidence for the existence of a constitutive nitric oxide synthase in vascular smooth muscle.

  title={Evidence for the existence of a constitutive nitric oxide synthase in vascular smooth muscle.},
  author={L S Cheah and Mce Gwee and Rapti Das and H Glenn Ballard and Yubo Yang and Edwin E. Daniel and Chiu-yin Kwan},
  journal={Clinical and experimental pharmacology & physiology},
  volume={29 8},
1. We have identified a neuronal nitric oxide synthase (NOS)-like constitutive form of NOS in vascular smooth muscle (VSM) using a functional contractility approach as well as immunohistochemical methods. 2. N(G)-Nitro-L-arginine methyl ester, N(G)-monomethyl-L- arginine and N(G)-nitro-L-arginine (L-NOARG), the competitive inhibitors of NOS, inhibited Mg(2+)-induced relaxation of de-endothelialized rat aorta precontracted with phenylephrine (PE). This Mg(2+) relaxation of VSM was not affected… CONTINUE READING


Publications citing this paper.
Showing 1-7 of 7 extracted citations

Skeletal muscle contraction-induced vasodilator complement production is dependent on stimulus and contraction frequency.

American journal of physiology. Heart and circulatory physiology • 2009
View 5 Excerpts
Highly Influenced

The role of oxidative stress in acetylcholine-induced relaxation of endothelium-denuded arteries.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society • 2013
View 2 Excerpts

Perinatal lead exposure affects nitric oxide and cyclooxygenase pathways in aorta of weaned rats.

Toxicological sciences : an official journal of the Society of Toxicology • 2008
View 1 Excerpt

Maturation depresses mouse cerebrovascular tone through endothelium-dependent mechanisms.

American journal of physiology. Regulatory, integrative and comparative physiology • 2003
View 1 Excerpt

Similar Papers

Loading similar papers…