Evidence for the exchange of arterial spin-labeled water with tissue water in rat brain from diffusion-sensitized measurements of perfusion.

@article{Silva1997EvidenceFT,
  title={Evidence for the exchange of arterial spin-labeled water with tissue water in rat brain from diffusion-sensitized measurements of perfusion.},
  author={Afonso C. Silva and Donald S. Williams and Alan P. Koretsky},
  journal={Magnetic resonance in medicine},
  year={1997},
  volume={38 2},
  pages={232-7}
}
The extraction fraction of vascular water in rat brain is investigated by means of diffusion measurements of arterial spin labeled water at varying cerebral blood flow (CBF) values. The apparent diffusion coefficient (ADC) of the difference of the proton magnetization signal in the brain acquired with and without continuous arterial spin labeling is modeled to provide a measure of the amount of arterial water in tissue and vasculature and thus of the extraction fraction. The tissue and vascular… CONTINUE READING