Evidence for the efficacy of statins in animal stroke models: a meta-analysis.

@article{GarcaBonilla2012EvidenceFT,
  title={Evidence for the efficacy of statins in animal stroke models: a meta-analysis.},
  author={Lidia Garc{\'i}a-Bonilla and Mireia Campos and D. Gallardo Giralt and David H. Salat and Pilar Chac{\'o}n and Mar Hern{\'a}ndez-Guillamon and Anna Perdrix Rosell and Joan Montaner},
  journal={Journal of neurochemistry},
  year={2012},
  volume={122 2},
  pages={
          233-43
        }
}
Protective effects of statins have been well documented for stroke therapy. Here, we used a systematic review and meta-analysis to assess these evidences. We identified 190 studies using statin treatment in stroke animal models by electronic searching. From those, only studies describing ischemic occlusive stroke and reporting data on infarct volume and/or neurological outcome were included in the analysis (41 publications, 1882 animals). The global estimate effect was assessed by Weighted Mean… CONTINUE READING

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