Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation.

@article{Allers2011EvidenceFT,
  title={Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation.},
  author={K. Allers and G. Huetter and J. Hofmann and C. Loddenkemper and K. Rieger and E. Thiel and T. Schneider},
  journal={Blood},
  year={2011},
  volume={117 10},
  pages={
          2791-9
        }
}
  • K. Allers, G. Huetter, +4 authors T. Schneider
  • Published 2011
  • Biology, Medicine
  • Blood
  • HIV entry into CD4(+) cells requires interaction with a cellular receptor, generally either CCR5 or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral replication remained absent despite discontinuation of antiretroviral therapy after transplantation with CCR5Δ32/Δ32 stem cells. However, it was expected that the long-lived viral reservoir would lead to HIV rebound and disease progression during the process of immune reconstitution. In the present study, we… CONTINUE READING
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    References

    SHOWING 1-10 OF 53 REFERENCES
    Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy.
    • 450
    • PDF
    Primary HIV-1 Infection Is Associated with Preferential Depletion of CD4+ T Lymphocytes from Effector Sites in the Gastrointestinal Tract
    • 1,120
    • PDF
    Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation.
    • 1,404
    • PDF