Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation.

@article{Allers2011EvidenceFT,
  title={Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation.},
  author={Kristina Allers and Gero Huetter and Jörg Hofmann and Christoph Loddenkemper and Kathrin Rieger and Eckhard Thiel and Thomas Ian Schneider},
  journal={Blood},
  year={2011},
  volume={117 10},
  pages={
          2791-9
        }
}
  • Kristina Allers, Gero Huetter, +4 authors Thomas Ian Schneider
  • Published in Blood 2011
  • Medicine
  • HIV entry into CD4(+) cells requires interaction with a cellular receptor, generally either CCR5 or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral replication remained absent despite discontinuation of antiretroviral therapy after transplantation with CCR5Δ32/Δ32 stem cells. However, it was expected that the long-lived viral reservoir would lead to HIV rebound and disease progression during the process of immune reconstitution. In the present study, we… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 51 REFERENCES

    Is HIV Eradication Feasible

    • C. De Mendoza
    • AIDS Rev
    • 2009

    Long-term control of HIV by CCR5 Delta32/Delta32 stemcell transplantation

    • G Hütter, D Nowak, M Mossner
    • N Engl J Med
    • 2009

    Not an HIV cure, but encouraging new directions.

    • Jay A. Levy
    • Medicine
    • The New England journal of medicine
    • 2009