Evidence for the critical role of interleukin-12 but not interferon-gamma in the pathogenesis of experimental colitis in mice.

@article{Tozawa2003EvidenceFT,
  title={Evidence for the critical role of interleukin-12 but not interferon-gamma in the pathogenesis of experimental colitis in mice.},
  author={Kotaro Tozawa and Hiroyuki Hanai and Ken Sugimoto and S. El Baba and Haruhiko Sugimura and Taiki Aoshi and Masato Uchijima and Toshi Nagata and Yukio Koide},
  journal={Journal of gastroenterology and hepatology},
  year={2003},
  volume={18 5},
  pages={578-87}
}
BACKGROUND AND AIMS The imbalance between helper T (Th)1/Th2 cytokines has been observed in human inflammatory bowel disease and various animal models. Because interleukin (IL)-12 and interferon-gamma (IFN-gamma) productions are known to be a hallmark of Th1-dominant intestinal inflammation such as 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis, we strictly addressed the roles of IFN-gamma and IL-12 in the development of colitis, employing knockout mice with IFN-gamma receptor (IFN… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…