Evidence for the contribution of insulin resistance to the development of cachexia in tumor-bearing mice.

@article{Asp2010EvidenceFT,
  title={Evidence for the contribution of insulin resistance to the development of cachexia in tumor-bearing mice.},
  author={Michelle L. Asp and Min Tian and Angela A. Wendel and Martha A. Belury},
  journal={International journal of cancer},
  year={2010},
  volume={126 3},
  pages={756-63}
}
Cancer cachexia is a syndrome of unintentional weight loss that is characterized by wasting of both skeletal muscle and adipose tissue. Glucose intolerance and insulin resistance have been associated with cancer cachexia. However, it is unknown whether resistance to insulin has a role in the development of cachexia. In the present study, male CD2F1 mice with colon-26 adenocarcinoma tumors underwent an insulin tolerance test before the onset of weight loss. Compared to mice without tumors, mice… CONTINUE READING

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