Evidence for the binding of a biologically active interleukin-2 to human alpha 2-macroglobulin.

@article{Legrs1995EvidenceFT,
  title={Evidence for the binding of a biologically active interleukin-2 to human alpha 2-macroglobulin.},
  author={Luc Legr{\`e}s and F Pochon and M Barray and Françoise Gay and Salem Chouaib and Etienne Delain},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 15},
  pages={8381-4}
}
Human alpha 2-macroglobulin (alpha 2M), which irreversibly entraps proteinases through a drastic conformational change, has also been reported to bind various cytokines. The meaning of cytokine binding to native and/or transformed alpha 2M molecules is, however, not understood. In an attempt to elucidate this question, we have studied the interaction of radioiodinated recombinant human interleukin-2 (125I-rhIL-2) with native and chymotrypsin (alpha 2M-C)- or methylamine-transformed (alpha 2M-MA… CONTINUE READING