Evidence for the binding mode of porphyrins to G-quadruplex DNA.

  title={Evidence for the binding mode of porphyrins to G-quadruplex DNA.},
  author={Chun-ying Wei and G. Z. Jia and Jun Zhou and Gaoyi Han and Can Li},
  journal={Physical chemistry chemical physics : PCCP},
  volume={11 20},
Interactions of porphyrin derivatives 5,10,15,20-tetrakis(N-methylpyridinium-4-yl)-21H,23H-porphyrin (TMPyP4) and 5,10,15,20-tetrakis(N-propylpyridinium-4-yl)-21H,23H-porphyrin (TPrPyP4) with human telomeric AG(3)(T(2)AG(3))(3) G-quadruplex DNAs in 150 mM K(+)-containing buffer in the presence or absence of 40% molecular crowding agent poly(ethylene glycol) (PEG 200) were studied by absorption titration fitting and time-resolved fluorescence spectroscopy. The results show that two TMPyP4 (or… CONTINUE READING


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