Evidence for the association of protein 4.1 immunoreactive forms with neurofibrillary tangles in Alzheimer's disease brains

  title={Evidence for the association of protein 4.1 immunoreactive forms with neurofibrillary tangles in Alzheimer's disease brains},
  author={R. Sihag and L. Wang and A. Cataldo and M. Hamlin and R. Nixon},
  journal={Brain Research},
  • R. Sihag, L. Wang, +2 authors R. Nixon
  • Published 1994
  • Biology, Medicine
  • Brain Research
  • The formation of neurofibrillary tangles (NFTs) and paired-helical filaments (PHFs) in Alzheimer's disease (AD) reflects a major disorganization of the cytoskeleton. The role of the neuronal membrane skeleton in the development of these abnormalities has not previously been investigated. In this study, we used 9 antibodies raised against the erythrocyte membrane skeleton protein 4.1 (P4.1) for immunocytochemical and immunoblot analyses to investigate whether or not the brain homologues of this… CONTINUE READING
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