Evidence for the Pauling–Corey α-Helix in Synthetic Polypeptides

  title={Evidence for the Pauling–Corey $\alpha$-Helix in Synthetic Polypeptides},
  author={William G. Cochran and Francis H. C. Crick},
WE have calculated, in collaboration with Dr. V. Vand1, the Fourier transform (or continuous structure factor) of an atom repeated at regular intervals on an infinite helix. The properties of the transform are such that it will usually be possible to predict the general character of X-ray scattering by any structure based on a regular succession of similar groups of atoms arranged in a helical manner. In particular, the type of X-ray diffraction picture given by the synthetic polypeptide poly… 
25 Citations
Structure of the Synthetic Polypeptide Poly-γ-methyl-L-glutamate
WE have made a check on the assignment of the α-helix with eighteen residues in five turns to poly-γ-methyl-L-glutamate1 by preparing and interpreting X-ray photographs of a sample of the material.
The stability and screw sense of the α-helix in poly-β-benzyl-L-aspartate
A number of polymers and copolymers containing β-benzyl-L-aspartate has been prepared and their optical rotatory dispersion in a variety of solvents has been measured. The results of these
William Astbury and the biological significance of nucleic acids, 1938-1951.
  • Kersten Hall
  • Physics
    Studies in history and philosophy of biological and biomedical sciences
  • 2011
Is α-Keratin a Coiled Coil?
ALL recent work1–6 has confirmed that the structure of the synthetic polypeptide poly-γ-methyl-L-glutamate is based on the α-helix of Pauling and Corey7. This structure gives a strong 1.5-A.
REVIEW ARTICLES: First stages in the x-ray analysis of proteins
The paper describes the many attempts, lasting over nearly a quarter of a century, which finally led to the analysis of the structure of a protein molecule by X rays. At each stage fragments of
Studies in History and Philosophy of Biological and Biomedical Sciences
Drawing on previously unpublished archival sources, a new analysis of Astbury’s relationship to the problem of DNA's structure is offered, emphasizing a previously overlooked element in Astbury's thinking: his concept of biological specificity.
Synthesis and chemical properties of poly-alpha-amino acids.
Coiled coils: attractive protein folding motifs for the fabrication of self-assembled, responsive and bioactive materials.
This critical review will end with a section that summarizes the different coiled coil based (hybrid) materials that have been reported to date and which hopefully will help to stimulate further work to explore the full potential of this unique class of protein folding motifs for the development of novel self-assembled, responsive and/or bioactive materials.


The structure of synthetic polypeptides.
  • L. Pauling, R. Corey
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1951
Evidence that one of the helical structures is assumed also by synthetic polypeptides is discussed, which is an important structural feature of hemoglobin and other globular proteins.
New X-Ray Evidence on the Configuration of Polypeptide Chains: Polypeptide Chains in Poly-γ-benzyl-L-glutamate, Keratin and Hæmoglobin
  • M. Perutz
  • Biology, Materials Science
  • 1951
New X-Ray Evidence on the Configuration of Polypeptide Chains: Polypeptide Chains in Poly-γ-benzyl-L-glutamate, Keratin and Haemoglobin