Evidence for the Pauling–Corey α-Helix in Synthetic Polypeptides

@article{Cochran1952EvidenceFT,
  title={Evidence for the Pauling–Corey $\alpha$-Helix in Synthetic Polypeptides},
  author={William G. Cochran and Francis H. C. Crick},
  journal={Nature},
  year={1952},
  volume={169},
  pages={234-235}
}
WE have calculated, in collaboration with Dr. V. Vand1, the Fourier transform (or continuous structure factor) of an atom repeated at regular intervals on an infinite helix. The properties of the transform are such that it will usually be possible to predict the general character of X-ray scattering by any structure based on a regular succession of similar groups of atoms arranged in a helical manner. In particular, the type of X-ray diffraction picture given by the synthetic polypeptide poly… 
26 Citations
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References

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The structure of synthetic polypeptides.
  • L. Pauling, R. Corey
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1951
TLDR
Evidence that one of the helical structures is assumed also by synthetic polypeptides is discussed, which is an important structural feature of hemoglobin and other globular proteins.
New X-Ray Evidence on the Configuration of Polypeptide Chains: Polypeptide Chains in Poly-γ-benzyl-L-glutamate, Keratin and Hæmoglobin
  • M. Perutz
  • Biology, Materials Science
    Nature
  • 1951
New X-Ray Evidence on the Configuration of Polypeptide Chains: Polypeptide Chains in Poly-γ-benzyl-L-glutamate, Keratin and Haemoglobin