# Evidence for the Pauling–Corey α-Helix in Synthetic Polypeptides

@article{Cochran1952EvidenceFT,
title={Evidence for the Pauling–Corey $\alpha$-Helix in Synthetic Polypeptides},
author={William G. Cochran and Francis H. C. Crick},
journal={Nature},
year={1952},
volume={169},
pages={234-235}
}
• Published 1 February 1952
• Biology
• Nature
WE have calculated, in collaboration with Dr. V. Vand1, the Fourier transform (or continuous structure factor) of an atom repeated at regular intervals on an infinite helix. The properties of the transform are such that it will usually be possible to predict the general character of X-ray scattering by any structure based on a regular succession of similar groups of atoms arranged in a helical manner. In particular, the type of X-ray diffraction picture given by the synthetic polypeptide poly…
26 Citations
Structure of the Synthetic Polypeptide Poly-γ-methyl-L-glutamate
• Chemistry
Nature
• 1952
WE have made a check on the assignment of the α-helix with eighteen residues in five turns to poly-γ-methyl-L-glutamate1 by preparing and interpreting X-ray photographs of a sample of the material.
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Is α-Keratin a Coiled Coil?
ALL recent work1–6 has confirmed that the structure of the synthetic polypeptide poly-γ-methyl-L-glutamate is based on the α-helix of Pauling and Corey7. This structure gives a strong 1.5-A.
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• 2010
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Francis Harry Compton Crick OM. 8 June 1916 — 28 July 2004
• Chemistry
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• 2017
The first half of the twentieth century saw a profound change in the authors' understanding of the chemistry underlying biology, and no person was more influential in shaping and guiding this emerging field than Francis Crick.

## References

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The structure of synthetic polypeptides.
• Biology, Chemistry
Proceedings of the National Academy of Sciences of the United States of America
• 1951
Evidence that one of the helical structures is assumed also by synthetic polypeptides is discussed, which is an important structural feature of hemoglobin and other globular proteins.
New X-Ray Evidence on the Configuration of Polypeptide Chains: Polypeptide Chains in Poly-γ-benzyl-L-glutamate, Keratin and Hæmoglobin
• M. Perutz
• Biology, Materials Science
Nature
• 1951
New X-Ray Evidence on the Configuration of Polypeptide Chains: Polypeptide Chains in Poly-γ-benzyl-L-glutamate, Keratin and Haemoglobin