Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target.

Abstract

Ubiquitination and ubiquitin-like posttranslational modifications (PTM) regulate activity and stability of oncoproteins and tumor suppressors. This implicates PTMs as antineoplastic targets. One way to alter PTMs is to inhibit activity of deubiquitinases (DUB) that remove ubiquitin or ubiquitin-like proteins from substrate proteins. Roles of DUBs in… (More)
DOI: 10.1158/0008-5472.CAN-17-1752

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