Evidence for the Existence of Triple-Negative Variants in the MCF-7 Breast Cancer Cell Population

@inproceedings{Leung2014EvidenceFT,
  title={Evidence for the Existence of Triple-Negative Variants in the MCF-7 Breast Cancer Cell Population},
  author={Euphemia Y Leung and Ji Eun Kim and Marjan E Askarian-Amiri and Graeme Finlay and B. C. Baguley},
  booktitle={BioMed research international},
  year={2014}
}
The MCF-7 line, derived in 1973 from a malignant pleural effusion, is one of the most commonly used culture models for human breast cancer. Despite its long history, MCF-7 is a surprisingly heterogeneous line. We previously showed that if MCF-7 cells were cultured for a prolonged period either in the absence of estrogen or in the presence of the antiestrogen tamoxifen, sub-lines were selected that differed from the parental line in ploidy, mean cell volume, signaling pathway usage, and drug… CONTINUE READING