Evidence for targeted vesicular glutamate exocytosis in osteoblasts.

  title={Evidence for targeted vesicular glutamate exocytosis in osteoblasts.},
  author={P S Bhangu and Paul Genever and Gary J. Spencer and Tarlochan S Grewal and Timothy M. Skerry},
  volume={29 1},
Regulated intercellular signaling is essential for the maintenance of bone mass. In recent work we described how osteoblasts and osteoclasts express functional receptors for the excitatory amino acid, glutamate, indicating that a signaling pathway analogous to synaptic neurotransmission exists in bone. Here, we show that osteoblasts also express the essential molecular framework for regulated glutamate exocytosis to occur as is present in presynaptic neurons. A combination of reverse… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 31 extracted citations

Syntaxin 4a Regulates Matrix Vesicle-Mediated Bone Matrix Production by Osteoblasts.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2017
View 1 Excerpt

Sigma receptors [σRs]: biology in normal and diseased states

Journal of receptor and signal transduction research • 2015
View 1 Excerpt

Crosstalk between the brain and bone.

Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases • 2012
View 1 Excerpt

Glutamate signaling in bone

Front. Endocrin. • 2012
View 2 Excerpts

Similar Papers

Loading similar papers…