Evidence for targeted vesicular glutamate exocytosis in osteoblasts.

@article{Bhangu2001EvidenceFT,
  title={Evidence for targeted vesicular glutamate exocytosis in osteoblasts.},
  author={P S Bhangu and Paul Genever and Gary J. Spencer and Tarlochan S Grewal and Timothy M. Skerry},
  journal={Bone},
  year={2001},
  volume={29 1},
  pages={16-23}
}
Regulated intercellular signaling is essential for the maintenance of bone mass. In recent work we described how osteoblasts and osteoclasts express functional receptors for the excitatory amino acid, glutamate, indicating that a signaling pathway analogous to synaptic neurotransmission exists in bone. Here, we show that osteoblasts also express the essential molecular framework for regulated glutamate exocytosis to occur as is present in presynaptic neurons. A combination of reverse… CONTINUE READING

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