Evidence for substantial fine-scale variation in recombination rates across the human genome

@article{Crawford2004EvidenceFS,
  title={Evidence for substantial fine-scale variation in recombination rates across the human genome},
  author={D. Crawford and T. Bhangale and N. Li and G. Hellenthal and M. Rieder and D. Nickerson and M. Stephens},
  journal={Nature Genetics},
  year={2004},
  volume={36},
  pages={700-706}
}
Characterizing fine-scale variation in human recombination rates is important, both to deepen understanding of the recombination process and to aid the design of disease association studies. Current genetic maps show that rates vary on a megabase scale, but studying finer-scale variation using pedigrees is difficult. Sperm-typing experiments have characterized regions where crossovers cluster into 1–2-kb hot spots, but technical difficulties limit the number of studies. An alternative is to use… Expand

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References

SHOWING 1-10 OF 36 REFERENCES
A high-resolution recombination map of the human genome
Linkage disequilibrium in humans: models and data.
...
1
2
3
4
...