Evidence for substantial fine-scale variation in recombination rates across the human genome

@article{Crawford2004EvidenceFS,
  title={Evidence for substantial fine-scale variation in recombination rates across the human genome},
  author={Dana C. Crawford and Tushar R. Bhangale and Na Li and Garrett Hellenthal and Mark J. Rieder and Deborah A. Nickerson and Matthew Stephens},
  journal={Nature Genetics},
  year={2004},
  volume={36},
  pages={700-706}
}
Characterizing fine-scale variation in human recombination rates is important, both to deepen understanding of the recombination process and to aid the design of disease association studies. Current genetic maps show that rates vary on a megabase scale, but studying finer-scale variation using pedigrees is difficult. Sperm-typing experiments have characterized regions where crossovers cluster into 1–2-kb hot spots, but technical difficulties limit the number of studies. An alternative is to use… CONTINUE READING

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